What key combination is typically used to save a document in Office applications?

The key combination typically used to save a document in Office applications is Ctrl + S. This command is a standard shortcut across many software applications and is designed to trigger the save function, which ensures that the content of the document is stored to the hard drive or other specified location. Utilizing this shortcut allows users to quickly save their progress without needing to navigate through menus, enhancing productivity and workflow efficiency.

In most environments, Ctrl + P is used for printing, Ctrl + Z serves as the undo command for reversing the last action taken, and Ctrl + C is the command for copying selected text or objects. Each of these other shortcuts serves an important function, but none fulfill the primary role of saving the document, which is why Ctrl + S is the correct choice here.